Ginsenoside Rg1 augments oxidative metabolism and anabolic response of skeletal muscle in mice.

ABSTRACT:

Background

The ginsenoside Rg1 has been shown to exert various pharmacological activities with health benefits. Previously, we have reported that Rg1 promoted myogenic differentiation and myotube growth in C2C12 myoblasts. In this study, the in vivo effect of Rg1 on fiber-type composition and oxidative metabolism in skeletal muscle was examined.

Methods

To examine the effect of Rg1 on skeletal muscle, 3-month-old mice were treated with Rg1 for 5 weeks. To assess muscle strength, grip strength tests were performed, and the lower hind limb muscles were harvested, followed by various detailed analysis, such as histological staining, immunoblotting, immunostaining, and real-time quantitative reverse transcription polymerase chain reaction. In addition, to verify the in

SUBMITTER: Jeong HJ 

PROVIDER: S-EPMC6606823 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature