MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34.

ABSTRACT: The etiology and pathophysiology of anxiety and mood disorders is linked to inappropriate regulation of the central stress response. To determine whether microRNAs have a functional role in the regulation of the stress response, we inactivated microRNA processing by a lentiviral-induced local ablation of the Dicer gene in the central amygdala (CeA) of adult mice. CeA Dicer ablation induced a robust increase in anxiety-like behavior, whereas manipulated neurons survive and appear to exhibit normal gross morphology in the time period examined. We also observed that acute stress in wild-type mice induced a differential expression profile of microRNAs in the amygdala. Bioinformatic analysis identified putative gene targets for these stress-responsive microRNAs, some of which are known to be as

SUBMITTER: Haramati S 

PROVIDER: S-EPMC6623664 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature