Endogenous H₂S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer.

ABSTRACT: Overexpression of endogenous H₂S is one of the key characteristic in colon cancer. However, developing endogenous H₂S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H₂S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000-1,400 nm via endogenous H₂S-induced in situ chemical reaction to form Ag₂S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise locatio

SUBMITTER: Deng Z 

PROVIDER: S-EPMC6625970 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature