Ca²⁺ signalling behaviours of intramuscular interstitial cells of Cajal in the murine colon.

ABSTRACT:

Key points

Colonic intramuscular interstitial cells of Cajal (ICC-IM) exhibit spontaneous Ca²⁺ transients manifesting as stochastic events from multiple firing sites with propagating Ca²⁺ waves occasionally observed. Firing of Ca²⁺ transients in ICC-IM is not coordinated with adjacent ICC-IM in a field of view or even with events from other firing sites within a single cell. Ca²⁺ transients, through activation of Ano1 channels and generation of inward current, cause net depolarization of colonic muscles. Ca²⁺ transients in ICC-IM rely on Ca²⁺ release from the endoplasmic reticulum via IP₃ receptors, spatial amplification from RyRs and ongoing refilling of ER via the sarcoplasmic/endoplasmic-reticulum-Ca

SUBMITTER: Drumm BT 

PROVIDER: S-EPMC6629484 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature