CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program.
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ABSTRACT:
SUBMITTER: Thaventhiran T
PROVIDER: S-EPMC6634261 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program.
Thaventhiran Thilipan T Wong Wai W Alghanem Ahmad F AF Alhumeed Naif N Aljasir Mohammad A MA Ramsey Simeon S Sethu Swaminathan S Yeang Han Xian Aw HXA Chadwick Amy E AE Cross Michael M Webb Steven D SD Djouhri Laiche L Ball Christina C Stebbings Richard R Sathish Jean G JG
Monoclonal antibodies in immunodiagnosis and immunotherapy 20190401 2
CD28 superagonist (CD28SA), a therapeutic immunomodulatory monoclonal antibody triggered rapid and exaggerated activation of CD4<sup>+</sup> effector memory T cells (T<sub>EMs</sub>) in humans with unwanted serious adverse effects. It is well known that distinct metabolic programs determine the fate and responses of immune cells. In this study, we show that human CD4<sup>+</sup> T<sub>EMs</sub> stimulated with CD28SA adopt a metabolic program similar to those of tumor cells with enhanced glucose ...[more]
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