Endometrial safety of low-dose vaginal estrogens in menopausal women: a systematic evidence review.

ABSTRACT:

Objective

The aim of the study was to systematically review studies that evaluated endometrial hyperplasia or cancer incidence with unopposed vaginal estrogens.

Methods

PubMed and EMBASE were searched from inception to August 2017 for relevant articles and abstracts. Bibliographies of review articles and abstracts of major women's health medical meetings were examined. Eligible studies (independently reviewed by 4 authors) had to report menopausal vaginal estrogen use and endometrial histology, or incidence of endometrial hyperplasia or cancer.

Results

Of 5,593 abstracts from the literature search and 47 articles from other sources, 36 articles and 2 abstracts were eligible, describing 20 randomized controlled studies, 8 interventional studies, and 10 observational st

SUBMITTER: Constantine GD 

PROVIDER: S-EPMC6636806 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature