Comparative genomic analysis revealed great plasticity and environmental adaptation of the genomes of Enterococcus faecium.

ABSTRACT:

Background

As an important nosocomial pathogen, Enterococcus faecium has received increasing attention in recent years. However, a large number of studies have focused on the hospital-associated isolates and ignored isolates originated from the natural environments.

Results

In this study, comparative genomic analysis was conducted on 161 isolates originated from human, animal, and naturally fermented dairy products. The results showed that the environment played an important role in shaping the genomes of Enterococcus faecium. The isolates from human had the largest average genome size, while the isolates from dairy products had the smallest average genome size and fewest antibiotic resistance genes. A phylogenetic tree was reconstructed based on the genomes of these isolate

SUBMITTER: Zhong Z 

PROVIDER: S-EPMC6647102 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature