C-Terminal Plays as the Possible Nucleation of the Self-Aggregation of the S-Shape Aβ_11-42 Tetramer in Solution: Intensive MD Study.

ABSTRACT: Amyloid beta (Aβ) peptides are characterized as the major factors associated with neuron death in Alzheimer's disease, which is listed as the most common form of neurodegeneration. Disordered Aβ peptides are released from proteolysis of the amyloid precursor protein. The Aβ self-assembly process roughly takes place via five steps: disordered forms → oligomers → photofibrils → mature fibrils → plaques. Although Aβ fibrils are often observed in patient brains, oligomers were recently indicated to be major neurotoxic elements. In this work, the neurotoxic compound S-shape Aβ_11-42 tetramer (S4Aβ_11-42) was investigated over 10 μs of unbiased MD simulations. In particular, the S4Aβ_11-42 oligomer adopted a high dynamics structure, resulting in unsuccessful determi

SUBMITTER: Tung NT 

PROVIDER: S-EPMC6648102 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature