Early second-line therapy is associated with improved episodic memory in anti-NMDA receptor encephalitis.

ABSTRACT:

Objective

To investigate whether the early administration of intravenous second-line immunotherapy correlates with improved long-term cognition and the potential mechanisms via imaging in adult patients with moderate-to-severe anti-N-methyl-D-aspartate (NMDA) receptor encephalitis.

Methods

Sixteen adult patients with moderate-to-severe anti-NMDA receptor encephalitis past the acute stage and 15 healthy controls (HCs) performed a set of comprehensive neuropsychological tests, and underwent a resting-state fMRI study to analyze resting state functional connectivity (FC). In addition, correlation analyses were performed between hippocampal FC and cognitive performance. All patients were received intravenous first-line immunotherapy, and nine of them were also given intravenous

SUBMITTER: Wang K 

PROVIDER: S-EPMC6649545 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature