Modelling reactive case detection strategies for interrupting transmission of Plasmodium falciparum malaria.

ABSTRACT:

Background

As areas move closer to malaria elimination, a combination of limited resources and increasing heterogeneity in case distribution and transmission favour a shift to targeted reactive interventions. Reactive case detection (RCD), the following up of additional individuals surrounding an index case, has the potential to target transmission pockets and identify asymptomatic cases in them. Current RCD implementation strategies vary, and it is unclear which are most effective in achieving elimination.

Methods

OpenMalaria, an established individual-based stochastic model, was used to simulate RCD in a Zambia-like setting. The capacity to follow up index cases, the search radius, the initial transmission and the case management coverage were varied. Suitable settings wer

SUBMITTER: Reiker T 

PROVIDER: S-EPMC6668148 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature