Hippocampal neurons in direct contact with astrocytes exposed to amyloid β_25-35 exhibit reduced excitatory synaptic transmission.

ABSTRACT: Amyloid β protein (Aβ) is closely related to the progression of Alzheimer's disease because senile plaques consisting of Aβ cause synaptic depression and synaptic abnormalities. In the central nervous system, astrocytes are a major glial cell type that contribute to the modulation of synaptic transmission and synaptogenesis. In this study, we examined whether astrocytes exposed to Aβ fragment 25-35 (Aβ_25-35) affect synaptic transmission. We show that synaptic transmission by hippocampal neurons was inhibited by astrocytes exposed to Aβ_25-35. The Aβ_25-35-exposed astrocytes lowered excitatory postsynaptic release and the size of the readily releasable synaptic pool. The number of excitatory synapses was also reduced. However, the number of excitatory synapses

SUBMITTER: Oyabu K 

PROVIDER: S-EPMC6669318 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature