Hippocampal neurons in direct contact with astrocytes exposed to amyloid ?_25-35 exhibit reduced excitatory synaptic transmission.

ABSTRACT: Amyloid ? protein (A?) is closely related to the progression of Alzheimer's disease because senile plaques consisting of A? cause synaptic depression and synaptic abnormalities. In the central nervous system, astrocytes are a major glial cell type that contribute to the modulation of synaptic transmission and synaptogenesis. In this study, we examined whether astrocytes exposed to A? fragment 25-35 (A?_25-35) affect synaptic transmission. We show that synaptic transmission by hippocampal neurons was inhibited by astrocytes exposed to A?_25-35. The A?_25-35-exposed astrocytes lowered excitatory postsynaptic release and the size of the readily releasable synaptic pool. The number of excitatory synapses was also reduced. However, the number of excitatory synapses was unchanged unless there was direct contact between A?_25-35-exposed astrocytes and hippocampal neurons. These data indicate that direct contact between A?_25-35-exposed astrocytes and neurons is critical for inhibiting synaptic transmission in the progression of Alzheimer's disease.

SUBMITTER: Oyabu K 

PROVIDER: S-EPMC6669318 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature