A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota.
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ABSTRACT:
SUBMITTER: Coyne MJ
PROVIDER: S-EPMC6671954 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota.
Coyne Michael J MJ Béchon Nathalie N Matano Leigh M LM McEneany Valentina Laclare VL Chatzidaki-Livanis Maria M Comstock Laurie E LE
Nature communications 20190801 1
Bacteria often produce antimicrobial toxins to compete in microbial communities. Here we identify a family of broad-spectrum peptide toxins, named bacteroidetocins, produced by Bacteroidetes species. We study this toxin family using phenotypic, mutational, bioinformatic, and human metagenomic analyses. Bacteroidetocins are related to class IIa bacteriocins of Gram-positive bacteria and kill members of the Bacteroidetes phylum, including Bacteroides, Parabacteroides, and Prevotella gut species, a ...[more]
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