A statistical and biological response to an informatics appraisal of healthy aging gene signatures.

ABSTRACT: Jacob and Speed did not identify even a single example of a '150-gene-set' that was statistically significant at classifying Alzheimer's disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below.

SUBMITTER: Timmons JA 

PROVIDER: S-EPMC6676519 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature