Investigation of the variants at the binding site of inflammatory transcription factor NF-κB in patients with end-stage renal disease.

ABSTRACT:

Background

A chronic inflammatory state is a prominent feature in patients with end-stage renal disease (ESRD). Nuclear factor-kappa B (NF-κB) is a transcription factor that regulates the expression of genes involved in inflammation. Some genetic studies have demonstrated that the NF-κB genetic mutation could cause kidney injury and kidney disease progression. However, the association of a gene polymorphism in the transcription factor binding site of NF-κB with kidney disease is not clear.

Methods

We used the Taiwan Biobank database, the University of California, Santa Cruz, reference genome, and a chromatin immunoprecipitation sequencing database to find single nucleotide polymorphisms (SNPs) at potential binding sites of NF-κB. In addition, we performed a case-control stud

SUBMITTER: Yang JH 

PROVIDER: S-EPMC6683452 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature