Clinical efficacy of tadalafil compared to sildenafil in treatment of moderate to severe canine pulmonary hypertension: a pilot study.

ABSTRACT:

Introduction

Canine pulmonary hypertension (PH) is associated with high morbidity and mortality. Tadalafil, a phosphodiesterase-5 inhibitor used commonly in humans with PH, has not been evaluated in a clinical trial in dogs with naturally occurring PH. Our objectives were to compare the efficacy of tadalafil and sildenafil on PH assessed by peak tricuspid regurgitant flow velocity, estimated systolic pulmonary arterial pressure gradient, voluntary activity, quality of life, and safety profiles in dogs with moderate to severe PH.

Animals

Twenty-three dogs with echocardiographic evidence of moderate to severe PH were enrolled.

Methods

A prospective short-term, randomized, double-blinded pilot study was carried out. Dogs with PH were randomly allocated to receive sildena

SUBMITTER: Jaffey JA 

PROVIDER: S-EPMC6693640 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature