Sca-1⁺ cardiac fibroblasts promote development of heart failure.

ABSTRACT: The causative effect of GM-CSF produced by cardiac fibroblasts to development of heart failure has not been shown. We identified the pathological GM-CSF-producing cardiac fibroblast subset and the specific deletion of IL-17A signaling to these cells attenuated cardiac inflammation and heart failure. We describe here the CD45^- CD31^- CD29⁺ mEF-SK4⁺ PDGFRα⁺ Sca-1⁺ periostin⁺ (Sca-1⁺ ) cardiac fibroblast subset as the main GM-CSF producer in both experimental autoimmune myocarditis and myocardial infarction mouse models. Specific ablation of IL-17A signaling to Sca-1⁺ periostin⁺ cardiac fibroblasts (Postn^Cre Il17ra^fl/fl ) protected mice from post-infarct heart fai

SUBMITTER: Chen G 

PROVIDER: S-EPMC6696927 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature