Individual Effector/Regulator T Cell Ratios Impact Bone Regeneration.

ABSTRACT: There is increasing evidence that T lymphocytes play a key role in controlling endogenous regeneration. Regeneration appears to be impaired in case of local accumulation of CD8+ effector T cells (T_EFF), impairing endogenous regeneration by increasing a primary "useful" inflammation toward a damaging level. Thus, rescuing regeneration by regulating the heightened pro-inflammatory reaction employing regulatory CD4+ T (T_Reg) cells could represent an immunomodulatory option to enhance healing. Hypothesis was that CD4+ T_Reg might counteract undesired effects of CD8+ T_EFF. Using adoptive T_Reg transfer, bone healing was consistently improved in mice possessing an inexperienced immune system with low amounts of CD8+ T_EFF. In contras

SUBMITTER: Schlundt C 

PROVIDER: S-EPMC6706871 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature