Comparison of fimasartan and amlodipine therapy on carotid atherosclerotic plaque inflammation.

ABSTRACT:

Background

The renin-angiotensin system plays an important role in promoting atherosclerotic plaque inflammation, which may be inhibited by angiotension-II receptor blockers.

Hypothesis

We investigated the effects of fimasartan and amlodipine therapy on carotid atherosclerotic plaque inflammation using ¹⁸ F-fluorodeoxyglucose (¹⁸ FDG) positron emission tomography (PET) imaging.

Methods

Fifty patients with acute coronary syndrome (ACS) and at least one lesion with ¹⁸ FDG uptake in the carotid artery (target-to-background ratio [TBR] ≥ 1.6) were randomly assigned to receive either fimasartan (60 mg once a day) or amlodipine (5 mg once a day). ¹⁸ FDG PET examinations were performed in all patients at baseline and 6 months. The

SUBMITTER: Oh M 

PROVIDER: S-EPMC6712325 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature