Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila.

ABSTRACT: Coordinated intra- and inter-organ growth during animal development is essential to ensure a correctly proportioned individual. The Drosophila wing has been a valuable model system to reveal the existence of a stress response mechanism involved in the coordination of growth between adjacent cell populations and to identify a role of the fly orthologue of p53 (Dmp53) in this process. Here we identify the molecular mechanisms used by Dmp53 to regulate growth and proliferation in a non-autonomous manner. First, Dmp53-mediated transcriptional induction of Eiger, the fly orthologue of TNFα ligand, leads to the cell-autonomous activation of JNK. Second, two distinct signaling events downstream of the Eiger/JNK axis are induced in order to independently regulate tissue size and cell number in adj

SUBMITTER: Sanchez JA 

PROVIDER: S-EPMC6715248 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature