Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer.

ABSTRACT: High numbers of tissue-resident memory T (T_RM) cells are associated with better clinical outcomes in cancer patients. However, the molecular characteristics that drive their efficient immune response to tumors are poorly understood. Here, single-cell and bulk transcriptomic analysis of T_RM and non-T_RM cells present in tumor and normal lung tissue from patients with lung cancer revealed that PD-1-expressing T_RM cells in tumors were clonally expanded and enriched for transcripts linked to cell proliferation and cytotoxicity when compared with PD-1-expressing non-T_RM cells. This feature was more prominent in the T_RM cell subset coexpressing PD-1 and TIM-3, and it was validated by functional assays ex vivo and also reflected in

SUBMITTER: Clarke J 

PROVIDER: S-EPMC6719422 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature