Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer.

ABSTRACT: Therapies that boost the anti-tumor responses of cytotoxic T lymphocytes (CTLs) have shown promise; however, clinical responses to the immunotherapeutic agents currently available vary considerably, and the molecular basis of this is unclear. We performed transcriptomic profiling of tumor-infiltrating CTLs from treatment-naive patients with lung cancer to define the molecular features associated with the robustness of anti-tumor immune responses. We observed considerable heterogeneity in the expression of molecules associated with activation of the T cell antigen receptor (TCR) and of immunological-checkpoint molecules such as 4-1BB, PD-1 and TIM-3. Tumors with a high density of CTLs showed enrichment for transcripts linked to tissue-resident memory cells (T_RM cells), such as CD

SUBMITTER: Ganesan AP 

PROVIDER: S-EPMC6036910 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature