Viral MHCI inhibition evades tissue-resident memory T cell formation and responses.

ABSTRACT: Tissue-resident memory CD8⁺ T cells (T_RMs) confer rapid protection and immunity against viral infections. Many viruses have evolved mechanisms to inhibit MHCI presentation in order to evade CD8⁺ T cells, suggesting that these mechanisms may also apply to T_RM-mediated protection. However, the effects of viral MHCI inhibition on the function and generation of T_RMs is unclear. Herein, we demonstrate that viral MHCI inhibition reduces the abundance of CD4⁺ and CD8⁺ T_RMs, but its effects on the local microenvironment compensate to promote antigen-specific CD8⁺ T_RM formation. Unexpectedly, local cognate antigen enhances CD8⁺ T_RM development even in the context of vi

SUBMITTER: Lauron EJ 

PROVIDER: S-EPMC6314518 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature