PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer.

ABSTRACT:

Background

Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibody therapy. This study aimed to identify PD-1/PD-L1 correlated genes and pathways as well as investigate their potential as prognostic marker in BC.

Materials and methods

By analysing transcriptional data of BC from TCGA, we identified PD-1 and PD-L1 correlated genes by WGCNA analysis and explored the biological process as well as pathways they enriched. Co-expression analysis were performed for PD-1/PD-L1 with immune infiltration and checkpoints. The prognostic value of PD-1 and PD-L1 were also investigated.

Results

PD-1 and PD-L1 expression showed sig

SUBMITTER: Jiang C 

PROVIDER: S-EPMC6734479 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature