Visualization of clustered protocadherin neuronal self-recognition complexes.

ABSTRACT: Neurite self-recognition and avoidance are fundamental properties of all nervous systems¹. These processes facilitate dendritic arborization^2,3, prevent formation of autapses⁴ and allow free interaction among non-self neurons^1,2,4,5. Avoidance among self neurites is mediated by stochastic cell-surface expression of combinations of about 60 isoforms of α-, β- and γ-clustered protocadherin that provide mammalian neurons with single-cell identities^1,2,4-13. Avoidance is observed between neurons that express identical protocadherin repertoires^2,5, and single-isoform differences are sufficient to prevent self-recognition¹⁰. Protocadherins form isoform-promiscuous cis dimers and isoform-specific homophilic trans dimers<

SUBMITTER: Brasch J 

PROVIDER: S-EPMC6736547 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature