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Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes.

ABSTRACT: The development of bifunctional imaging probes can often be challenging with difficult and time-consuming solution phase chemistry protocols and purification techniques. A solid phase synthetic protocol was therefore utilized to produce a functionalized derivative of a potent bismacrocyclic calcium-responsive contrast agent for magnetic resonance imaging. Through a convenient building block approach, the applicability of this methodology in the preparation and simple future development of multifunctional imaging probes was demonstrated.

SUBMITTER: Connah L

PROVIDER: S-EPMC6750874 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes.

Connah Liam L Joshi Rajendra R Vibhute Sandip S Gambino Giuseppe G Correia João D G JDG Angelovski Goran G

Organic letters 20190531 14

The development of bifunctional imaging probes can often be challenging with difficult and time-consuming solution phase chemistry protocols and purification techniques. A solid phase synthetic protocol was therefore utilized to produce a functionalized derivative of a potent bismacrocyclic calcium-responsive contrast agent for magnetic resonance imaging. Through a convenient building block approach, the applicability of this methodology in the preparation and simple future development of multif ...[more]

PMID: 31150258

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