Large-Scale "OMICS" Studies to Explore the Physiopatholgy of HIV-1 Infection.

ABSTRACT: In this review, we present the main large-scale experimental studies that have been performed in the HIV/AIDS field. These "omics" studies are based on several technologies including genotyping, RNA interference, and transcriptome or epigenome analysis. Due to the direct connection with disease evolution, there has been a large focus on genotyping cohorts of well-characterized patients through genome-wide association studies (GWASs), but there have also been several invitro studies such as small interfering RNA (siRNA) interference or transcriptome analyses of HIV-1-infected cells. After describing the major results obtained with these omics technologies-including some with a high relevance for HIV-1 treatment-we discuss the next steps that the community needs to embrace in order to derive

SUBMITTER: Le Clerc S 

PROVIDER: S-EPMC6754074 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature