2-Aminoadipic acid (2-AAA) as a potential biomarker for insulin resistance in childhood obesity.

ABSTRACT: Insulin resistance is an important clinical feature of metabolic syndrome, which includes obesity and type 2 diabetes. Increased adipose energy storage in obesity promote insulin resistance and other metabolic adverse effects. To identify a new link between adipocyte and insulin resistance, we performed targeted metabolite profiling of differentiated adipocytes and studied the association between adipogenic metabolites and insulin resistance. We found a correlation between 2-aminoadipic acid (2-AAA) and adipogenic differentiation. Also, circulatory 2-AAA was positively associated with obesity-related factors (fat mass, fat percent, waist circumference, BMI, BMI z-score, triglycerides, insulin, and HOMA-IR) at baseline and after 2 years in the children cohort study. Of these factors, increa

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC6754510 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature