Ontology highlight
ABSTRACT:
SUBMITTER: Sim WJ
PROVIDER: S-EPMC6761206 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190925 1
Treatment of muscle-invasive bladder cancer remains a major clinical challenge. Aberrant HGF/c-MET upregulation and activation is frequently observed in bladder cancer correlating with cancer progression and invasion. However, the mechanisms underlying HGF/c-MET-mediated invasion in bladder cancer remains unknown. As part of a negative feedback loop SMAD7 binds to SMURF2 targeting the TGFβ receptor for degradation. Under these conditions, SMAD7 acts as a SMURF2 agonist by disrupting the intramol ...[more]