Serum Endocannabinoid Levels in Patients With End-Stage Renal Disease.

ABSTRACT:

Context

Previous studies have shown that the endocannabinoid system plays a major role in energy metabolism through the actions of its main mediators, 2-arachidonoyl-sn-glycerol (2-AG) and anandamide (AEA).

Objective

We examined serum levels of major endocannabinoid mediators and their association with clinical parameters in patients with end-stage renal disease (ESRD).

Design and setting

Serum concentrations of 2-AG and AEA were measured in patients on maintenance hemodialysis (MHD) and controls, and correlations with various clinical and laboratory indices were examined. 2-AG was also measured in age and sex-matched healthy subjects for comparison of levels in patients undergoing MHD.

Main outcome measure

Serum 2-AG.

Results

Serum 2-AG levels we

SUBMITTER: Moradi H 

PROVIDER: S-EPMC6767629 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature