Essential role of IκB_NS for in vivo CD4⁺ T-cell activation, proliferation, and Th1-cell differentiation during Listeria monocytogenes infection in mice.

ABSTRACT: Acquisition of effector functions in T cells is guided by transcription factors, including NF-κB, that itself is tightly controlled by inhibitory proteins. The atypical NF-κB inhibitor, IκB_NS, is involved in the development of Th1, Th17, and regulatory T (Treg) cells. However, it remained unclear to which extend IκB_NS contributed to the acquisition of effector function in T cells specifically responding to a pathogen during in vivo infection. Tracking of adoptively transferred T cells in Listeria monocytogenes infected mice antigen-specific activation of CD4⁺ T cells following in vivo pathogen encounter to strongly rely on IκB_NS . While IκB_NS was largely dispensable for the acquisition of cytotoxic effector function in CD8⁺

SUBMITTER: Frentzel S 

PROVIDER: S-EPMC6771600 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature