Quantitative positron emission tomography reveals regional differences in aerobic glycolysis within the human brain.
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ABSTRACT:
SUBMITTER: Blazey T
PROVIDER: S-EPMC6775584 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Quantitative positron emission tomography reveals regional differences in aerobic glycolysis within the human brain.
Blazey Tyler T Snyder Abraham Z AZ Su Yi Y Goyal Manu S MS Lee John J JJ Vlassenko Andrei G AG Arbeláez Ana Maria AM Raichle Marcus E ME
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20180323 10
Glucose and oxygen metabolism are tightly coupled in the human brain, with the preponderance of the brain's glucose supply used to generate ATP via oxidative phosphorylation. A fraction of glucose is consumed outside of oxidative phosphorylation despite the presence of sufficient oxygen to do so. We refer to this process as aerobic glycolysis. A recent positron emission tomography study reported that aerobic glycolysis is uniform within gray matter. Here, we analyze the same data and demonstrate ...[more]
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