Myo-REG: A Portal for Signaling Interactions in Muscle Regeneration.

ABSTRACT: Muscle regeneration is a complex process governed by the interplay between several muscle-resident mononuclear cell populations. Following acute or chronic damage these cell populations are activated, communicate via cell-cell interactions and/or paracrine signals, influencing fate decisions via the activation or repression of internal signaling cascades. These are highly dynamic processes, occurring with distinct temporal and spatial kinetics. The main challenge toward a system level description of the muscle regeneration process is the integration of this plethora of inter- and intra-cellular interactions. We integrated the information on muscle regeneration in a web portal. The scientific content annotated in this portal is organized into two information layers representing relationship

SUBMITTER: Palma A 

PROVIDER: S-EPMC6776608 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature