Sleep Duration and Myocardial Infarction.

ABSTRACT:

Background

Observational studies suggest associations between extremes of sleep duration and myocardial infarction (MI), but the causal contribution of sleep to MI and its potential to mitigate genetic predisposition to coronary disease is unclear.

Objectives

This study sought to investigate associations between sleep duration and incident MI, accounting for joint effects with other sleep traits and genetic risk of coronary artery disease, and to assess causality using Mendelian randomization (MR).

Methods

In 461,347 UK Biobank (UKB) participants free of relevant cardiovascular disease, the authors estimated multivariable adjusted hazard ratios (HR) for MI (5,128 incident cases) across habitual self-reported short (<6 h) and long (>9 h) sleep duration, and examined jo

SUBMITTER: Daghlas I 

PROVIDER: S-EPMC6785011 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature