Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
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ABSTRACT: Purpose
This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis.Materials and methods
The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression.Results
Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth.Conclusion
Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.
SUBMITTER: Li N
PROVIDER: S-EPMC6790838 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
Li Nan N Piao Junjie J Wang Xinyue X Kim Ki-Yeol KY Bae Jung Yoon JY Ren Xiangshan X Lin Zhenhua Z
Cancer research and treatment 20190419 4
<h4>Purpose</h4>This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis.<h4>Materials and methods</h4>The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression.<h4>Results</h4>Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knoc ...[more]
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