Structure folding of RNA kissing complexes in salt solutions: predicting 3D structure, stability, and folding pathway.

ABSTRACT: RNA kissing complexes are essential for genomic RNA dimerization and regulation of gene expression, and their structures and stability are critical to their biological functions. In this work, we used our previously developed coarse-grained model with an implicit structure-based electrostatic potential to predict three-dimensional (3D) structures and stability of RNA kissing complexes in salt solutions. For extensive RNA kissing complexes, our model shows great reliability in predicting 3D structures from their sequences, and our additional predictions indicate that the model can capture the dependence of 3D structures of RNA kissing complexes on monovalent/divalent ion concentrations. Moreover, the comparisons with extensive experimental data show that the model can make reliable predicti

SUBMITTER: Jin L 

PROVIDER: S-EPMC6795135 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature