Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis.

ABSTRACT:

Background

The study aims at scientifically investigating the genetic effect of four polymorphisms (rs7975232, rs1544410, rs2228570, and rs731236) within the human Vitamin D Receptor (VDR) gene on the odds of psoriasis through an updated meta-analysis.

Methods

We searched eight databases and screened the studies for pooling. Finally, a total of eighteen eligible case-control studies were included. BH (Benjamini & Hochberg) adjusted P-values of association (P_association) and odd ratios (ORs) with the corresponding 95% confidence intervals (CIs) were calculated under the allele, homozygote, heterozygote, dominant, recessive, and carrier models.

Results

Compared with the negative controls, no statistically significant difference in the odds of psoriasis was de

SUBMITTER: Li J 

PROVIDER: S-EPMC6796361 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature