Alteration in TET1 as potential biomarker for immune checkpoint blockade in multiple cancers.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) have achieved impressive success in different cancer types, yet responses vary and predictive biomarkers are urgently needed. Growing evidence points to a link between DNA methylation and anti-tumor immunity, while clinical data on the association of genomic alterations in DNA methylation-related genes and ICI response are lacking.

Methods

Clinical cohorts with annotated response and survival data and matched mutational data from published studies were collected and consolidated. The predictive function of specific mutated genes was first tested in the discovery cohort and later validated in the validation cohort. The association between specific mutated genes and tumor immunogenicity and anti-tumor immunity was further investig

SUBMITTER: Wu HX 

PROVIDER: S-EPMC6798429 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature