Human immune globulin 10% with recombinant human hyaluronidase in multifocal motor neuropathy.

ABSTRACT:

Objective

The primary aim was to determine the safety of treatment with human immune globulin 10% with recombinant human hyaluronidase (fSCIg) compared to intravenous immunoglobulin (IVIg) in a prospective open-label study in patients with multifocal motor neuropathy (MMN).

Methods

Our study consisted of two phases: the IVIg phase (visits 1-3; 12 weeks), in which patients remained on IVIg treatment, and the fSCIg phase (visits 4-7; 36 weeks), in which patients received fSCIg treatment. After visit 3, IVIg was switched to an equivalent dose and frequency of fSCIg. Outcome measures were safety, muscle strength, disability and treatment satisfaction.

Results

Eighteen patients were enrolled in this study. Switching to fSCIg reduced the number of systemic adverse events (I

SUBMITTER: Herraets IJT 

PROVIDER: S-EPMC6803588 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature