Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049.

ABSTRACT: Microbes serve as the most important resource for drug discovery. During our screening for bioactive compounds from our natural products library, a pathogenic fungus, Microdochium majus strain 99049, from wheat was selected for further investigation. A new alkaloid named brocaeloid D (1), together with six previously characterized compounds (2-7) were identified. Compound 1 belongs to 4-oxoquinoline with C-2 reversed prenylation and a succinimide substructure. All the structures of these newly isolated compounds were determined by different means in spectroscopic experiments. The absolute configurations of 1 was further deduced from comparison of its CD spectrum with that of known compound 2. The bioactivities of these identified compounds w

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6807035 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature