Ontology highlight
ABSTRACT:
SUBMITTER: Gyukity-Sebestyen E
PROVIDER: S-EPMC6813737 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in immunology 20191018
Recently, it has been described that programmed cell death protein 1 (PD-1) overexpressing melanoma cells are highly aggressive. However, until now it has not been defined which factors lead to the generation of PD-1 overexpressing subpopulations. Here, we present that melanoma-derived exosomes, conveying oncogenic molecular reprogramming, induce the formation of a melanoma-like, PD-1 overexpressing cell population (mMSC<sup>PD-1+</sup>) from naïve mesenchymal stem cells (MSCs). Exosomes and mMS ...[more]