Novel Role for Claudin-11 in the Regulation of Osteoblasts via Modulation of ADAM10-Mediated Notch Signaling.
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ABSTRACT:
SUBMITTER: Lindsey RC
PROVIDER: S-EPMC6813858 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Novel Role for Claudin-11 in the Regulation of Osteoblasts via Modulation of ADAM10-Mediated Notch Signaling.
Lindsey Richard C RC Xing Weirong W Pourteymoor Sheila S Godwin Catrina C Gow Alexander A Mohan Subburaman S
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20190726 10
The claudin (Cldn) family comprises 27 members of 20 to 34 kDa transmembrane tight junction proteins. In addition to Cldns' established canonical role as barriers controlling paracellular flow of molecules, a distinct noncanonical role for them as mediators of cell signaling is now emerging. In our studies evaluating Cldn family expression levels during osteoblast differentiation, Cldn-11 showed the largest increase (60-fold). Immunohistochemistry studies revealed high Cldn-11 expression in trab ...[more]
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