MRP14 enhances the ability of macrophage to recruit T cells and promotes obesity-induced insulin resistance.

ABSTRACT:

Objective

Myeloid-related protein-14 (MRP14) and its binding partner MRP8 play an essential role in innate immune function and have been implicated in a variety of inflammatory diseases. However, the role of MRP14 in obesity-induced inflammation and insulin resistance is not well defined. This study investigated the role of MRP14 in macrophage-mediated adipose tissue inflammation and obesity-induced insulin resistance.

Subjects and results

Wild-type (WT) and Mrp14^-/- mice were fed with a high-fat diet or normal chow for 12 weeks. Tissue-resident macrophages in both adipose tissue and liver from obese WT mice expressed higher levels of MRP14 in the visceral adipose fat and liver compared with the lean mice. Mrp14^-/- mice demonstrated a significantly impr

SUBMITTER: Xia C 

PROVIDER: S-EPMC6821582 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature