Gadd45β promotes regeneration after injury through TGFβ-dependent restitution in experimental colitis.
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ABSTRACT:
SUBMITTER: Hwang JH
PROVIDER: S-EPMC6821912 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Gadd45β promotes regeneration after injury through TGFβ-dependent restitution in experimental colitis.
Hwang Jung Hwan JH Kim Tae-Hwan TH Kim Yong-Hoon YH Noh Jung-Ran JR Choi Dong-Hee DH Kim Kyoung-Shim KS Lee Eun-Young EY Kim Byoung-Chan BC Kim Myung Hee MH Kim Ho H Lee Tae Geol TG Lee Jong-Soo JS Lee Chul-Ho CH
Experimental & molecular medicine 20191030 10
Dysregulated immune responses and impaired function in intestinal epithelial cells contribute to the pathogenesis of inflammatory bowel disease (IBD). Growth arrest and DNA damage-inducible 45 beta (Gadd45β) has been implicated in the pathogenesis of various inflammatory symptoms. However, the role of Gadd45β in IBD is completely unknown. This study aimed to evaluate the role of Gadd45β in IBD. Gadd45β-KO mice exhibited drastically greater susceptibility to dextran sulfate sodium (DSS)-induced c ...[more]
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