Differential Gene Expression in Articular Cartilage and Subchondral Bone of Neonatal and Adult Horses.

ABSTRACT: Skeletogenesis is complex and incompletely understood. Derangement of this process likely underlies developmental skeletal pathologies. Examination of tissue-specific gene expression may help elucidate novel skeletal developmental pathways that could contribute to disease risk. Our aim was to identify and functionally annotate differentially expressed genes in equine neonatal and adult articular cartilage (AC) and subchondral bone (SCB). RNA was sequenced from healthy AC and SCB from the fetlock, hock, and stifle joints of 6 foals (≤4 weeks of age) and six adults (8-12 years of age). There was distinct clustering by age and tissue type. After differential expression analysis, functional annotation and pathway analysis were performed using PANTHER and Reactome. Approximately 1115 and 3574 g

SUBMITTER: Kemper AM 

PROVIDER: S-EPMC6826356 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature