Evaluating differential nanoparticle accumulation and retention kinetics in a mouse model of traumatic brain injury via K^trans mapping with MRI.

ABSTRACT: Traumatic brain injury (TBI) is a leading cause of injury-related death worldwide, yet there are no approved neuroprotective therapies that improve neurological outcome post-injury. Transient opening of the blood-brain barrier following injury provides an opportunity for passive accumulation of intravenously administered nanoparticles through an enhanced permeation and retention-like effect. However, a thorough understanding of physicochemical properties that promote optimal uptake and retention kinetics in TBI is still needed. In this study, we present a robust method for magnetic resonance imaging of nanoparticle uptake and retention kinetics following intravenous injection in a controlled cortical impact mouse model of TBI. Three contrast-enhancing nanoparticles with different hydrodyna

SUBMITTER: Miller HA 

PROVIDER: S-EPMC6834577 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature