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Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.

ABSTRACT: A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-O-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.

SUBMITTER: Yamamura H 

PROVIDER: S-EPMC6836745 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.

Yamamura Hatsuo H   Isshiki Kana K   Fujita Yusuke Y   Kato Hisato H   Katsu Takashi T   Masuda Kazufumi K   Osawa Kayo K   Miyagawa Atsushi A  

MedChemComm 20190717 8

A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-<i>O</i>-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells. ...[more]

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