Genome Investigation of a Cariogenic Pathogen with Implications in Cardiovascular Diseases.

ABSTRACT: The proportion of people suffering from cardiovascular diseases has risen by 34% in the last 15 years in India. Cardiomyopathy is among the many forms of CVD s present. Infection of heart muscles is the suspected etiological agent for the same. Oral pathogens gaining entry into the bloodstream are responsible for such infections. Streptococcus mutans is an oral pathogen with implications in cardiovascular diseases. Previous studies have shown certain strains of S. mutans are found predominantly within atherosclerotic plaques and extirpated valves. To decipher the genetic differences responsible for endothelial cell invasion, we have sequenced the genome of Streptococcus mutans B14. Pan-genome analysis, search for adhesion proteins through a special algorithm, and prote

SUBMITTER: Sujitha S 

PROVIDER: S-EPMC6842392 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature