Axon regeneration induced by environmental enrichment- epigenetic mechanisms.

ABSTRACT: Environmental enrichment is known to be beneficial for cognitive improvement. In many animal models of neurological disorders and brain injury, EE has also demonstrated neuroprotective benefits in neurodegenerative diseases and in improving recovery after stroke or traumatic brain injury. The exact underlying mechanism for these phenomena has been unclear. Recent findings have now indicated that neuronal activity elicited by environmental enrichment induces Ca²⁺ influx in dorsal root ganglion neurons results in lasting enhancement of CREB-binding protein-mediated histone acetylation. This, in turn, increases the expression of pro-regeneration genes and promotes axonal regeneration. This mechanism associated with neuronal activity elicited by environmental enrichment-mediated pat

SUBMITTER: Tang BL 

PROVIDER: S-EPMC6862393 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature