Changes in micronutrient and inflammation serum biomarker concentrations after a norovirus human challenge.

ABSTRACT:

Background

To accurately assess micronutrient status, it is necessary to characterize the effects of inflammation and the acute-phase response on nutrient biomarkers.

Objective

Within a norovirus human challenge study, we aimed to model the inflammatory response of C-reactive protein (CRP) and α-1-acid glycoprotein (AGP) by infection status, model kinetics of micronutrient biomarkers by inflammation status, and evaluate associations between inflammation and micronutrient biomarkers from 0 to 35 d post-norovirus exposure.

Methods

Fifty-two healthy adults were enrolled into challenge studies in a hospital setting and followed longitudinally; all were exposed to norovirus, half were infected. Post hoc analysis of inflammatory and nutritional biomarkers was performed. Sub

SUBMITTER: Williams AM 

PROVIDER: S-EPMC6885472 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature