Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT⁺ Endothelial Progenitor Cells.

ABSTRACT: Rationale: Disruption of alveologenesis is associated with severe pediatric lung disorders, including bronchopulmonary dysplasia (BPD). Although c-KIT⁺ endothelial cell (EC) progenitors are abundant in embryonic and neonatal lungs, their role in alveolar septation and the therapeutic potential of these cells remain unknown.Objectives: To determine whether c-KIT⁺ EC progenitors stimulate alveologenesis in the neonatal lung.Methods: We used single-cell RNA sequencing of neonatal human and mouse lung tissues, immunostaining, and FACS analysis to identify transcriptional and signaling networks shared by human and mouse pulmonary c-KIT⁺ EC progenitors. A mouse model of perinatal hyperoxia-induced lung injury was used to identify molecular me

SUBMITTER: Ren X 

PROVIDER: S-EPMC6888649 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature